The 21st Prof. K.V. Thomas Endowment Seminar and Fourth International Symposium on New Trends in Applied Chemistry (NTAC-2023) was organized by the Post Graduate and Research Department of Chemistry at Sacred Heart College, Thevara, from February 7th to 8th, 2023. The ceremonial inauguration was conducted by Prof. Dr. Sabu Thomas, Vice Chancellor of Mahatma Gandhi University, along with Nobel Laureate Prof. Dr. Ada E Yonath (Nobel Laureate in Chemistry - 2009), Prof. K. V. Thomas (Ex. M.P. and Former Minister of Consumer Affairs), Fr. Dr. Jose John CMI (Principal), Dr. Franklin John (General Convener), and Dr. Ramakrishnan S (Organizing Secretary). The event garnered significant attention around the globe due to the presence of distinguished Guests, Faculties, Research scholars and students.